Biophysics and Structural Bioinformatics Laboratory

  • imageBiophysics and Structural Bioinformatics Laboratory
  • Name: Hao-Jen Hsu (許豪仁)
  • Title: Associate professor
  • Highest Degree: Biomedical Engineering, National Yang Ming University, Taiwan, Ph.D.
  • Research expertise: Biophysics, Structural Bioinformatics, Computational Drug Discovery
  • E-mail:hjhsu32@mail.tcu.edu.tw
  • Office/ Laboratory Site: D904/D923
  •  Office/ Laboratory Tel.: +886-3-8565301 #2643/2644
  •  Research Interests:
    1.        Design and modeling of anti-inflammatory/anti-cancer therapeutic drugs
    2.        Modeling protein-protein interaction
    3.        Mechanisms of functions of ligand-gated ion channels
  •  Recent Research Grants:

NO.

associated agency

Research Grant

period

1

Ministry of Science and Technology Theoretical modeling and experimental investigations on ligand binding mechanism of G-protein coupled receptors at atomic and molecular levels (II)(III) 2016/8/1~

2017/7/31

2

Industrial Technology Research Institute The study on development of de novo peptide derived from cytokine receptors to inhibit dialysis and severe sepsis 2015/9/15~

2016/9/14

3

Ministry of Science and Technology Theoretical modeling and experimental investigations on ligand binding mechanism of G-protein coupled receptors at atomic and molecular levels 2015/8/1~

2016/7/31

4

Ministry of Science and Technology n silico investigation of chemokine-receptor interactions: toward the understanding of the binding

mechanism and the design of anti-inflammatory peptide based drugs

2014/8/1~

2015/7/31

5

Ministry of Science and Technology Simulation study on the gating mechanism of ligand-gated ion channels(3/3) 2013/8/1~

2014/7/31

6

Ministry of Science and Technology Simulation study on the gating mechanism of ligand-gated ion channels(2/3) 2012/8/1~

2013/7/31

7

Ministry of Science and Technology Simulation study on the gating mechanism of ligand-gated ion channels(1/3) 2011/11/1~

2012/7/31

  • Recent Publications:

NO.

Title

Index

Publish Date

Journal

Author

1

Ribosome Protein L4 is essential for Epstein–Barr Virus Nuclear Antigen 1 function SCI 2616/2 Proc. Natl. Acad. Sci. USA. 113(8): 2229-2234

CL SHEN,

CD LIU,

RI You,

YH Ching,

HC Chen,

HJ Hsu,

JW Liou,

CW Peng*

2

Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1

SCI 2015/12 Scientific Reports ,5:18638:1-14

SJ Jiang,

JW Liou,

CC Chang,

Y Chung,

LF Lin,

HJ Hsu*

3

Structure based computational assessment of channel properties of assembled ORF-8a from SARS-CoV SCI 2015/2 PROTEINS: Structure, Function, and Bioinformatics, 83:300-308

HJ Hsu,

MH Lin,

C. Schindler,

WB Fischer*

4

Membrane undulation induced by NS4A of Dengue virus – a molecular dynamics simulation study SCI 2014/10 J. Biomol. Struc. Dyn.

Lin, M-H

Hsu, H-J

Fischer, W. B.*

5

In Silico Analysis Reveals Sequential Interactions and Protein Conformational Changes During the Binding of Chemokine CXCL-8 to its Receptor CXCR1 SCI 2014/4 PLOS ONE

Liou, J. W.

Chang, F. T.

Chung, Y.

Chen, W. Y.

Fischer, W. B.

Hsu, H. J.*

6

Membrane undulation induced by NS4A of Dengue virus – a molecular dynamics simulation study

SCI

2013/8

J. Biomol. Struc. Dyn.

Lin, M.H.,

Hsu, H.J.,

Bartenschlager, R.,

Fischer, W.B.

7

Computational modeling of the p7 monomer from HCV and its interaction with small molecule drugs

SCI

2013/7

Springer Plus

2:324

Yi-Ting Wang,

Hao-Jen Hsu,

Wolfgang B Fischer

8

Assembling viral channel forming proteins: Vpu from HIV-1

SCI

2013/1(in press)

Biopolymers

Li, L. H.
Hsu, H. J.
Fischer, W. B.*

9

PEDV ORF3 encodes an ion channel protein and regulates virus production.

SCI

2012/

FEBS Lett.
586:384-391

Wang, K
Lu, W
Chen, J
Xie, S
Shi, H
Hsu, H. J.
Yu, W
Xu, K
Bian, C
Fischer, WB
Schwarz, W
Sun, B.*

10

In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV.

SCI

2011/

J. Mol. Mod.
18:501-514

Hsu, H. J.
Fischer, W. B.*

11

ORF 8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.

SCI

2011/

Biochim. Biophys. Acta
1808:572-579

Hsu, H. J.

Henklein, P
Chen, Y-MA
Fischer, WB*

12

Viral channel forming proteins – modelling the target.

SCI

2011/

Biochim. Biophys. Acta
1808:561-571

Hsu, H. J.
Fischer, WB*