Molecular cell biology laboratory

  • 陳泓吉-1Molecular cell biology laboratory
  •  Name: Hong-Chi Chen (陳泓吉)
  •  Title: Assistant professor
  •  Highest Degree: Genetics, the Pennsylvania State University (USA), Ph.D.
  •  Research expertise: Molecular biology, Signal transduction
  •  E-mail:hhc117@mail.tcu.edu.tw
  •  Office/ Laboratory Site: D910/D917
  •  Office/ Laboratory Tel.: +886-3-8565301 #2628/2629 
  •  Research Interests:
    My lab is working on a component of atherosclerosis — vascular smooth muscles, and, therefore, is working on the basic research related to cardiovascular diseases and diabetes complication.  We are interested in investigating the signal transduction events that contribute to the transcriptional regulation of plasminogen activator inhibitor-1, a key regulator of fibrinolysis, in vascular smooth muscle cells. 
  •  Recent Research Grants:

NO.

associated agency

Research Grant

period

1

National Science Council

Investigating the roles of protein kinase C-theta in vascular cells (3/3)

2012/8/1 ~ 2013/7/31

2

National Science Council

Investigating the roles of protein kinase C-theta in vascular cells (2/3)

2011/8/1 ~ 2012/7/31

3

National Science Council

Investigating the roles of protein kinase C-theta in vascular cells (1/3)

2010/8/1 ~ 2011/7/31

4

Tzu Chi Foundation

Mechanistic insight of cyclooxygenase-2 induction by latent membrance protein 1 in EBV associated cancers, and effects of green tea catechins on LMP1-associated signaling

2009/8/1 ~ 2010/7/31

 

  • Research Publications:

NO.

Title

Index

Publish Date

Journal

Author

1

NbRABG3f, a member of Rab GTPase, is involved in Bamboo mosaic virus infection in Nicotiana benthamiana SCI 2016/5 Molecular Plant Pathology ,17:714-726

YP Huang,

JH Jhuo,

MS Tsai,

CH Tsai,

HC Chen,

NS Lin,

YH Hsu,

CP Cheng*

2

Ribosome Protein L4 is essential for Epstein–Barr Virus Nuclear Antigen 1 function SCI 2016/2 Proc. Natl. Acad. Sci. USA. 113(8): 2229-2234

CL SHEN,

CD LIU,

RI You,

YH Ching,

HC Chen,

HJ Hsu,

JW Liou,

CW Peng*

3

Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2.

SCI

2007/6

Blood
(109:p.5447~p.5454)

Chih-Wen Peng,

Bo Zhao,

Hong-Chi Chen,

Min-Luen Chou,

Chiou-Yan Lai,

Shinn-Zong Lin,

Hsue-Yin Hsu,

 and Elliott Kieff*

4

MEK1, 2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation.

SCI

2004/

Blood,103:2636-2644

Chen, HC

Feener, EP*

5

P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells.

SCI

2000/

Arteriosclerosis, Thrombosis and Vascular Biology,20:866-873

Bouchie, JL

Chen, HC

Carney, R

Bagot, JC

Wilden, PA

Feener, EP*

6

Role of the angiotensin AT1 receptor in rat aortic and cardiac PAI-1 expression.

SCI

2000/

Arteriosclerosis, Thrombosis and Vascular Biology,20:2297-2302

Chen, HC

Bouchie, JL

Perez, AS

Clermont, AC

Feener, EP*

7

Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells.

SCI

1997/

Blood,90:3533-3545

Joneja, B

Chen, HC

Seshasayee, D

Wrentmore, AL

Wojchowski, DM*

8

A surface mutant (F82R) of a human alpha-glutathione S-transferase shows decrease thermal stability and a new mode of molecular association in the crystal.

SCI

1994/

Protein,20:259-263

Zeng, K

Rose, JP

Chen, HC

Strickland, CL

Tu, C-P

Wang, BC*