彭致文 教授

彭致文-1聯絡方式:分機2627
辦公室/實驗室位置:D908/D916
Emailpengcw@mail.tcu.edu.tw
網頁:http://ponponslab.weebly.com/
學歷:美國奧瑞岡州立大學病毒學博士
專長:分子病毒學、基因表現與調控、分子腫瘤及基因治療
開設課程:病毒學、基因治療、基因表現與調控、動物細胞培養技術
實驗室名稱:病毒腫瘤實驗室
研究領域簡介:
癌症發生的成因非常複雜,包含環境因子,細胞自體變異及病毒感染等。EB病毒是最早發現和腫瘤相關的病源之一,它以獨特的多樣性潛伏期感染分別和淋巴癌、鼻咽癌產生高度相關性。我們以探討EB病毒潛伏感染的分子模式藉以開發可能的抗病毒模式。

 

.近五年研究計畫:

序號 補助或委託機構 計畫名稱 起訖年月 擔任的工作
1 科技部 EB病毒潛伏感染分子機轉的探討(3/3) 2014/8/1~2015/7/31 主持人
2 國家衛生研究院 miRNAs及細胞素在EB病毒致病力的機制探討 2014/1/1~2014/12/31 主持人
3 科技部 EB病毒潛伏感染分子機轉的探討(2/3) 2013/8/1~2014/7/31 主持人
4 國家衛生研究院 EB病毒核抗原1調控的轉錄機制及以細胞為高通量抗EB病毒藥物篩選平台的建立 2013/1/1 ~ 2013/12/31 主持人
5 科技部 EB病毒潛伏感染分子機轉的探討(1/3) 2012/8/1 ~ 2013/7/31 主持人
6 國家衛生研究院 EB病毒核抗原1調控的轉錄機制及以細胞為高通量抗EB病毒藥物篩選平臺的建立Y3 2012/1/1 ~ 2012/12/31 主持人
7 國家衛生研究院 EB病毒核抗原1調控的轉錄機制及以細胞為高通量抗EB病毒藥物篩選平臺的建立Y2 2011/1/1 ~ 2011/12/31 主持人
8 科技部 EB病毒核抗原2和前導蛋白所引導潛伏感染的分子機制探討(3/3) 2010/8/1 ~ 2011/7/31 主持人
9 國家衛生研究院 EB病毒核抗原1調控的轉錄機制及以細胞為高通量抗EB病毒藥物篩選平臺的建立Y1 2010/1/1 ~ 2010/12/31 主持人

 

.近五年期刊論文:

序號

題目

索引資料庫

發表年月

(出版年月)

期刊名稱

(卷次:頁次 )

作者

1

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

SCI

2014/7

Autophagy

Huang, YH

Yang, PM

Chuah, QY

Lee, YJ

Hsieh, YF

Peng, CW

Chiu, SJ

2

Nucleolin is important for Epstein–Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription

SCI

2014/1

Proc Natl Acad Sci USA

Chen, YL

Liu, CD

Cheng, CP

Zhao, B

Hsu, HJ

Shen, CL

Chiu, SJ

Kieff, E

Peng, CW*

3

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

SCI

2013/4

Scientific Reports,3:1675-1685

Yi-Chu Yu,

Pei-Ming Yang,

Qiu-Yu Chuah,

Yao-Huei Huang,

Chih-Wen Peng,

Yi-Jang Lee,

Shu-Jun Chiu*

4

Modulation of Epstein-Barr Virus Nuclear Antigen 2-Dependent Transcription by Protein Arginine Methyltransferase 5

SCI

2013/1

Biochemical and Biophysical Research Communications
(430:p.1097~p.1102)

Cheng-Der Liu,

Chi-Ping Cheng,

Jia-Shih Fang,

Ling-Chih Chen,

Bo Zhao,

Elliott Kieff,

Chih-Wen Peng*

5

The Nuclear Chaperone Nucleophosmin Escorts an Epstein-Barr Virus Nuclear Antigen to Establish Transcriptional Cascades for Latent Infection in Human B Cells

SCI

2012/12

PLOS Pathogen
(8:p.1~p.16)

Cheng-Der Liu,

Ya-Lin Chen,

Yi-Li Min,

Bo Zhao,

Chi-Ping Cheng,

Myung-Soo Kang,

Shu-Jun Chiu,

Elliott Kieff,

Chih-Wen Peng*

6

Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7- associated apoptosis and inhibition of autophagy

SCI

2012/2

INTERNATIONAL JOURNAL OF ONCOLOGY
(40:p.469~p.478)

PEI-MING YANG,

HO-HSING TSENG,

CHIH-WEN PENG,

WEN-SHU CHEN,

SHU-JUN CHIU*

7

EGCG debilitates the persistence of EBV latency by reducing the DNA binding potency of nuclear antigen 1

SCI

2012/1

Biochemical and Biophysical Research Communications
(417:p.1093~p.1099)

Ya-Lin Chen,

Hsing-Lyn Tsai,

Chih-Wen Peng*

8

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

SCI

2011/9

Proc Natl Acad Sci U S A.
(108:p.14902~p.14907)

Bo Zhao,

James Zou,

Hongfang Wang,

Eric Johannsen,

Chih-wen Peng,

John Quackenbush,

Jessica C. Mar,

Cynthia Casson Morton,

Matthew L. Freedman,

Stephen C. Blacklow,

Jon C. Aster,

Bradley E. Bernstein,

Elliott Kieff*

9

Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and phagocytosis in vitro.

SCI

2011/5

Oncol Rep.
(25:p.1373~p.1380)

TSUNG-LANG CHIU*,

CHIH-WEN PENG and MEI-JAN WANG

10

The XopE2 effector protein of Xanthomonas campestris pv. vesicatoria is involved in virulence and in the suppression of the hypersensitive response

SCI

2011/1

Botanical Studies
(52:p.55~p.72)

Rong-Hwa LIN,

Chih-Wen PENG,

Yuan-Chuen LIN,

Hwei-Ling PENG,

Hsiou-Chen

HUANG*

11

Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis

SCI

2011/1

Cancer Letters
(300:p.96~p.104)

Sz-Hsien Yu,

Pei-Ming Yang,

Chih-Wen Peng,

Yi-Chu Yu,

Shu-Jun Chiu*

12

AAV2-mediated interleukin-12 in the treatment of malignant brain tumors through activation of NK cells

SCI

2009/12

INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2009 Dec;35(6):1361-7.
(35:p.1361~p.1367)

TSUNG-LANG CHIU*,

SHINN-ZONG LIN,

WAN-HUA HSIEH,

CHIH-WEN PENG

13

Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis.

SCI

2009/9

Life Sci. 2009 Sep 23;85(13-14):517-25.
(85:p.517~p.525)

Yao-Jen Chang,

Jen-Wea Liu,

Po-Cheng Lin,

Li-Yi Sun,

Chih-Wen Peng,

Geng-Hong Luo,

Tse-Min Chen,

Ru-Ping Lee,

Shinn-Zong Lin,

Horng-Jyh Harn,

Tzyy-Wen Chiou*