徐雪瑩 教授

徐雪瑩-1

徐雪瑩教授

.聯絡方式:校內分機2613、實驗室分機2610

.辦公室/實驗室位置:D830/D829

Emailhsueyin@mail.tcu.edu.tw

.網頁:http://ls.tcu.edu.tw/hyhsu/news.php

.學歷:高雄醫學大學醫學研究所博士

.專長:細胞凋亡、放射生物效應、抗癌藥物研發

.開設課程:細胞凋亡、動物組織學、輻射生物學

.實驗室名稱:藥物研發與癌症治療實驗室

.研究領域簡介:

研究領域概分為:1.抗癌藥物的開發、2.抗氧化藥物的醫學應用。近年的研究主軸皆以天然物為素材,進行新藥功能的開發研究,在藥物分析及化學合成的新穎技術支援下,目前已證實多項具有生物功能發展潛力的藥物,例如可能取代或合併化療用藥之抗癌藥物及修補個體氧化傷害的天然成份等。相關研究方向主要為抗癌、抑制癌轉移(metastasis)、抗血管新生(angiogenesis)及抗氧化壓力等。再者,也以病毒感染與腫瘤發展之作用機制為題,進行抗癌策略之可行性評估。

 

.近年研究計畫: 

序號

補助或委託機構

計畫名稱

起訖年月

擔任的工作

1

慈濟醫療志業

發展以雷公藤輔助治療僵直性脊柱炎之研究(2/2)

2017/7/1~

2018/6/30

主持人

2

慈濟醫療志業

發展以雷公藤輔助治療僵直性脊柱炎之研究(1/2)

2016/7/1~

2017/6/30

主持人

3

行政院衛生署中醫藥委員會

雷公藤對Cisplatin抑制腫瘤生長及血管新生知交互作用(2-2)

2013/1/22~

2013/12/15

主持人

4

行政院衛生署中醫藥委員會

甘草與茶多酚併用之輻射保護功能評估

2011/7/19 ~

2011/12/31

主持人

 

.近年期刊論文:

序號

題目

索引資料庫

發表年月

(出版年月)

期刊名稱

(卷次:頁次 )

作者

1

Prolonged induction activates Cebpα independent adipogenesis in NIH/3T3 cells.

SCI

2013/1

PLoSOne

(2013: e51459)

Hsiao-Yun Shao,

Hsue-Yin Hsu,

Kuan-Sju Wu,

Siow-Wey Hee,

Lee-Ming Chuang,

Jih-I Yeh

2

Antimigratory Effects of theMethanol Extract fromMomordica charantia on Human Lung Adenocarcinoma CL1 Cells

SCI

2012/11

Evidence-Based Complementary and Alternative Medicine
(2012:p.819632~p.819643)

Hsue-Yin Hsu*,

Jung-Hsuan Lin,

Chia-Jung Li,

Shih-Fang Tsang,

Chun-Hao Tsai,

Jong-Ho Chyuan,

Shu-Jun Chiu,

Shuang-En Chuang*

3

Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways

SCI

2012/9

Evidence-Based Complementary and Alternative Medicine
(2012:p.261971~p.261981)

Chia-Jung Li,

Shih-Fang Tsang,

Chun-Hao Tsai,

Hsin-Yi Tsai,

Jong-Ho Chyuan,

Hsue-Yin Hsu*

4

Induction of Apoptosis by Ethanolic Extract of Corchorus olitorius Leaf in Human Hepatocellular Carcinoma (HepG2) Cells via a Mitochondria-Dependent Pathway

SCI

2012/8

Molecules
(17:p.9348~p.9360)

Chia-Jung Li,

Shang-Yu Huang,

Meng-Yu Wu,

Yu-Ching Chen,

Shih-Fang Tsang,

Jong-Ho Chyuan*

Hsue-Yin Hsu *

5

Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway

SCI

2012/7

Toxicology and Applied Pharmacology
(264:p.104~p.113)

Hsiao-Ling Tseng,

Chia-Jung Li,

Lin-Huang Huang,

Chun-Yao Chen,

Chun-Hao Tsai,

Chun-Nan Lin*,

Hsue-Yin Hsu*

6

Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo

SCI

2012/1

Cancer Letters
(319:p.203~p.213)

Chia-Jung Li,

Ching-Yu Chu,

Lin-Huang Huang,

 Ming-Hseng Wangb,

Lai-Fa Sheu,

Jih-I. Yeh*,

Hsue-Yin Hsu *

7

Kazinol Q from Broussonetia kazinoki Enhances Cell Death Induced by Cu(ll) through Increased Reactive Oxygen Species

SCI

2011/4

Molecules
(16:p.3212~p.3221)

Bai-Luh Wei,

Ying-Chieh Chen,

Hsue-Yin Hsu*

8

Widespread expression of prostate apoptosis response-4 (Par-4) in nasopharyngeal carcinoma.

SCI

2010/7

Head & Neck
(32.7:p.877~p.885)

Jeng-Woei Lee*,

Wei-Ting Hsiao,

Kuei-Fang Lee,

 Lai-Fa Sheu,

Hsue-Yin Hsu,

Lee-Ping Hsu,

Borcherng Su,

Moon-Sing Lee,

Yih-Chih Hsu,

Chung-Hsing Chang

9

Depletion of Securin Induces Senescence After Irradiation and Enhances Radiosensitivity in Human Cancer Cells Regardless of Functional p53 Expression

SCI

2010/6

International Journal of Radiation Oncology Biology and Physic
(77:p.566~p.574)

WEN-SHU CHEN,

YI-CHU YU,

 YI-JANG LEE,

JI-HSHIUNG CHEN,

HSUE-YIN HSU,

SHU-JUN CHIU*

10

Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis

SCI

2009/3

Virology
(385:p.323~p.334)

Ping-Yuan Lin,

Jeng-Woei Lee,

Ming-Huei Liao,

Hsue-Yin Hsu,

Shu-Jun Chiu,

Hung-Jen Liu,

Wen-Ling Shih*