Molecular Oncology Laboratory

  • 李政偉-1Molecular Oncology Laboratory
  • Name: Jeng-Woei Lee (李政偉)
  • Title: Professor
  •  Highest Degree: Ph. D. in Institute of Microbiology, NationalTaiwanUniversity
  • Research expertise: Cancer Biology
  •  E-mail: jwlee@mail.tcu.edu.tw
  •  Office/ Laboratory Site: D903/D913
  •  Office/ Laboratory Tel.:038565301 #2620/2621
  • Research Interests: We are interested in understanding the developing mechanism of head and neck cancers, including oral cancer, nasopharyngeal carcinoma (NPC) and hypopharyngeal carcinoma (HPC). In this respect, we are for the fist time to demonstrate that Epstein-Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP-1) can down-regulate a pro-apoptosis protein, prostate apoptosis response-4 (Par-4) activity, conversely, induce a pivotal angiogenesis activator, hypoxia-inducible factor-1 (HIF-1) transcription. In addition, we have used microarray analysis to analyze the genes regulated by LMP1. Several genes related to metabolism, such as TCA cycle, are selected under investigation. We are also interested in investigating crosstalk between apoptosis and autophagy in HPC prognosis. Through miRNA microarray analysis, another interest of our lab is to study significance of differentially expressed miRNAs in repeated NPC recurrence. Another effort of our lab is to study a novel tumor suppressor and inhibition mechanism is currently under investigation
  •  Recent Research Grants:l

NO.

associated agency

Research Grant

period

1

Ministry of Science and Technology Role of prostate apoptosis response-4 (Par-4) in oral cancer and molecular mechanism analysis 2015/8/1~

2016/7/31

2

Tzu Chi Foundation Role of hypoxia-inducible factor -1 (HIF-1) on Epstein-Barr virus (EBV) latent membrane protein -1 (LMP-1)-mediated Warburg effect 2015/8/1~

2016/7/31

3

Ministry of Science and Technology

Dissection of hif-1 alpha gene transcription and post-transcription regulation by EBV LMP-1 as well as significance on LMP-1-mediated carcinogenesis

2014/8/1~

2015/7/31

4

Tzu Chi University

Study of relationship between apoptosis and autophagy by prostate apoptosis response-4 (Par-4) induction, as well as effects on hypopharyngeal carcinoma cells

2013/10/1~

2014/9/30

5

Ministry of Science and Technology

Study on mechanisms of HIF-1 alpha gene transcription regulation by EBV LMP-1, and influence on LMP-1 induced Warburg effect

2012/8/1 ~ 2013/7/31

6

Ministry of Science and Technology

Effect of irradiation or drug sensitivity of hypopharyngeal carcinoma cells by prostate apoptosis respoanse-4 (Par-4) (2/2)

2011/8/1 ~ 2012/7/31

7

Tzu Chi Foundation

Study of prostate apoptosis response-4 (Par-4) repression by EBV LMP1 in nasopharyngeal carcinoma cells

2011/8/1 ~ 2012/7/31

 

  • Recent Publications:  

NO.

Title

Index

Publish Date

Journal

Author

1

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

SCI

2014/9

Journal of the Formosan Medical Association

Yang, DF

Lee, J W

Chen, HM

Hsu, YC

2

Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase.

SCI

2014/9

Photodiagnosis Photodyn Ther.

Tang, DF

Chen, JH

Chiang, CP

Huang, Z

Lee, J W

Liu, CJ

Chang, JL

Hsu, YC*

3

Differential miRNA expression in repeated recurrence of nasopharyngeal carcinoma

SCI

2014/3

Cancer Letters ,344:188-194

Ling-Jung Wang

Jeng Woei Lee *

Yu-Fu Chou

Peir-Rong Chen

Borcherng Su

Yih-Chih Hsu

Chung-Hsing Chang

4

Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 (Par-4) in hypopharyngeal carcinoma cells

SCI

2014/2

The American Journal of Pathology ,184:418-430

Ling-Jung Wang,

Peir-Rong Chen,

Lee-Ping Hsu,

Wen-Lin Hsu,

Dai-Wei Liu,

Chung-Hsing Chang,

Yih-Chih Hsu,

Jeng Woei Lee

5

Methotrexate enhances ALA-PDT-induced cytotoxicity in human SCC4 cells via the upregulation of coproporphyrinogen oxidase

SCI

2014/2

Journal of the Formosan Medical Association ,113:88-93

Deng-Fu Yang

Jeng Woei Lee

Hsin-Ming Chen

Zheng Huang

Yih-Chih Hsu*

6

Monocyte Chemotactic Protein 1 (MCP-1) Modulates Pro-Survival Signaling to Promote Progression of Head and Neck Squamous Cell Carcinoma

SCI

2014/2

PLoS ONE ,9:88952-88952

Wen-Tsai Ji

Hau-Ren Chen

Chun-Hsuan Lin

Jeng Woei Lee

Ching-Chih Lee

7

Relevance of Ultrastructural Alterations of Intercellular Junction Morphology in Inflamed Human Esophagus

其他(有審查機制)

2013/7

J Neurogastroenterol Motil ,19:324-331

Chia-Chin Liu,

Jeng Woei Lee,

Tso-Tsai Liu,

Chih-Hsun Yi,

Chien-Lin Chen*

8

Successful treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical 5-aminolevulinic acid-mediated photodynamic therapy

SCI

2012/4(in press)

  Photodiagnosis and Photodynamic Therapy

Yang, DF

Chiang, CP

Lee, JW

Tseng, MK

Hsu, YC*

9

Effective treatment of DMBA-induced hamster buccal pouch cancer lesions by topical photosan-mediated photodynamic therapy

SCI

2011/1(in press)

  Head&Neck

Chiang, CP

Huang, WT

Lee, JW

Hsu YC*

10

Identification of antibacterial mechanism of l-amino acid oxidase derived from harzianum ETS 323 Trichoderma.

SCI

2011/9

FEBS J
(278:p.3381~p.3394)

Yang, CA

Cheng, CH

Liu, SY

Lo, CT

Lee, JW

Peng, KC*

11

A Novel L-Amino Acid Oxidase from Trichoderma harzianum ETS 323 Associated with Antagonism of Rhizoctonia solani

SCI

2011/5

J. Agric. Food Chem
(59:p.4519~p.4526)

Yang, CA

Cheng, CH

Lo, CT

Liu, SY

Lee, JW *

Peng, CK*

12

Avian reovirus S1133-induced DNA damage signaling and subsequent apoptosis in cultured cells and in chickens

SCI

2011/

Arch Virol
(156:p.1917~p.1929)

Lin, PY

Liu, HJ

Chang, CD

Chang, CI

Hsu, JL

Liao, MH

Lee, JW

Shih, WL*